{"id":8339,"date":"2022-03-31T16:34:07","date_gmt":"2022-03-31T08:34:07","guid":{"rendered":"https:\/\/www.phytogaia.com\/?p=8339"},"modified":"2022-07-13T14:36:17","modified_gmt":"2022-07-13T06:36:17","slug":"2","status":"publish","type":"post","link":"https:\/\/www.phytogaia.com\/index.php\/2022\/03\/31\/2\/","title":{"rendered":"Pneumo-Protective Effects of Palm Tocotrienol and Carotene Complex in Pulmonary Fibrosis"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8339\" class=\"elementor elementor-8339\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-55e76bd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"55e76bd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cc3c95e\" data-id=\"cc3c95e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-89ab283 elementor-widget elementor-widget-heading\" data-id=\"89ab283\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pneumo-Protective Effects of Palm Tocotrienol and Carotene Complex in Pulmonary Fibrosis\n\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-15426dd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"15426dd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-45020fb\" data-id=\"45020fb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-396690d elementor-widget elementor-widget-image\" data-id=\"396690d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"612\" height=\"408\" src=\"https:\/\/www.phytogaia.com\/wp-content\/uploads\/2022\/03\/istockphoto-942696360-612x612-1.jpg\" class=\"attachment-large size-large wp-image-8341\" alt=\"\" srcset=\"https:\/\/www.phytogaia.com\/wp-content\/uploads\/2022\/03\/istockphoto-942696360-612x612-1.jpg 612w, https:\/\/www.phytogaia.com\/wp-content\/uploads\/2022\/03\/istockphoto-942696360-612x612-1-300x200.jpg 300w\" sizes=\"(max-width: 612px) 100vw, 612px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2125785 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2125785\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2ad0f2d\" data-id=\"2ad0f2d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-483faa8 elementor-widget elementor-widget-text-editor\" data-id=\"483faa8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>March 29<sup>th<\/sup>, 2022 &#8211; New York, USA &#8211; Tocotrienol and carotene from palm fruits are important pneumo-protective agents against pulmonary fibrosis (PF) by restoring the antioxidant capacity and inhibiting pro-inflammatory cytokines. Histopathological findings revealed that palm tocotrienol and carotene complex treatments significantly ameliorates BLM-inducted lung injury, as reported in a recent study published in <em>Nutrients <\/em>by a team of researchers from Southeast University and the Malaysian Palm Oil Board Institute in China. PF is a chronic, progressive and ultimately terminal disease caused mainly by bacterial or viral infections. Recently, varying degrees of PF have been reported in post-COVID-19 patients.<\/p><p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1rem;\">In this study, lung fibrosis-induced Sprague-Dawley (SD) Rats were supplemented with either saline, palm tocotrienol complex (50, 200mg\/kg body weight per day), palm mixed carotene complex or a combination of palm tocotrienol (200mg\/kg body weight per day) and carotene (10mg\/kg body weight per day) for 28 days. The therapeutic ef\ufb01cacy of palm tocotrienol and carotene against Bleomycin (BLM)-induced lung fibrosis was investigated via the modulation of TGF-\u03b2\/Smad, PI3K\/Akt\/mTOR, and NF-\u03baB signaling pathways.<\/span><\/p><p>Both palm tocotrienol and palm carotene treatments were found to significantly restore the BLM-induced alterations in anti-inflammatory and antioxidant functions. The treatments appeared to show pneumo-protective effects through the upregulation of antioxidant status, downregulation of MMP-7 and inflammatory cytokine expressions (IL-1\u03b2, IL-6, MPO, TGF-\u03b21, and TNF-\u03b1), oxidative stress (MDA), and extracellular matrix (HYP and MMP- 7) and reduction in collagen accumulation.<\/p><p>These histopathological findings further confirmed that the supplementation of palm tocotrienol and carotene complex significantly attenuate BLM-induced lung injury or pulmonary fibrosis in rats. This is the first ever report that demonstrates that palm tocotrienol and carotene complex have a preventive role against BLM-induced PF in rats. The researchers concluded that palm tocotrienol and carotene complex may be a novel therapeutic compound to mitigate or attenuate PF.<\/p><p><em>\u00a0<\/em><em style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1rem;\">\u201cWe are encouraged by these new findings, since it is the first ever study that shows the potential of palm tocotrienol and carotene complex in the restoration of the antioxidant capacity in the lung and the inhibition of inflammatory cytokines as well as amelioration of lung injury. These results imply that these palm phytonutrients are synergistic in their action and may be useful as dietary supplements for post COVID-19 patients and pulmonary or lung health. Of course, this needs to be confirmed by clinical research.\u201d <\/em><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1rem;\">said by Dr. Guiju Sun, the lead researcher.<\/span><\/p><p>\u201c<em>Numerous reports presently reveal that a severe COVID-19 infection increases the risk of pulmonary fibrosis which is more common in persons with comorbidities such as diabetes, hypertension or cardiovascular disease. There is still no cure for PF. Thus, this new study is a welcomed news in the post COVID-19 era as we move into the endemic phase in dealing with it<\/em>,\u201d added Dr. Ariati Aris, Scientific Affairs Specialist at PhytoGaia.<\/p><p>\u201c<em>This finding adds to the growing scientific evidence that tocotrienol and carotene (extracted from palm fruits) are both synergistic in exerting powerful antioxidant and anti-inflammatory properties. PhytoGaia\u2019s TocoGaia<sup>TM<\/sup> (Tocotrienol) and CaroGaia<sup>TM<\/sup> (Carotene) are available in various forms to cater to different delivery systems such as softgel capsule, tablet, 2-piece gelatin capsule, functional foods and drinks. We look forward to working with brand owners in formulating science-driven products or multi-vitamins for antioxidant, lung and immune enhancement<\/em>,\u201d commented Mr Bryan See, Vice President of PhytoGaia.<\/p><p>References<\/p><ol><li>Lu, Y. <em>et al<\/em>. (2022). Potential \u201cTherapeutic\u201d Effects of Tocotrienol-Rich Fraction (TOCOTRIENOL) and Carotene \u201cAgainst\u201d Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-\/Smad, PI3K\/Akt\/mTOR and NF- B Signaling Pathways. <em>Nutrients<\/em>, 14, 1094.<\/li><li>George, P.M. et al. (2022). Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy. The <em>Lancet Respiratory Medicine<\/em>, 8:807-15.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Pneumo-Protective Effects of Palm Tocotrienol and Carotene Complex in Pulmonary Fibrosis March 29th, 2022 &#8211; New York, USA &#8211; Tocotrienol and carotene from palm fruits are important pneumo-protective agents against pulmonary fibrosis (PF) by restoring the antioxidant capacity and inhibiting pro-inflammatory cytokines. Histopathological findings revealed that palm tocotrienol and carotene complex treatments significantly ameliorates BLM-inducted [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84],"tags":[],"class_list":["post-8339","post","type-post","status-publish","format-standard","hentry","category-news-press-releases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pneumo-Protective Effects of Palm Tocotrienol and Carotene Complex in Pulmonary Fibrosis - PhytoGaia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phytogaia.com\/index.php\/2022\/03\/31\/2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pneumo-Protective Effects of Palm Tocotrienol and Carotene Complex in Pulmonary Fibrosis - PhytoGaia\" \/>\n<meta property=\"og:description\" content=\"Pneumo-Protective Effects of Palm Tocotrienol and Carotene Complex in Pulmonary Fibrosis March 29th, 2022 &#8211; New York, USA &#8211; Tocotrienol and carotene from palm fruits are important pneumo-protective agents against pulmonary fibrosis (PF) by restoring the antioxidant capacity and inhibiting pro-inflammatory cytokines. 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